Psychedelics & medical cannabis
A good trip for investors?
Last updated: 28 Jul 2022
Market 101
Forget popping pills at a rave or escaping to a hippie commune: if a new wave of startups have it their way, the future of psychedelics and cannabis will lie in controlled clinical settings complete with prescriptions and therapists. They’re pushing for a renaissance and a rebrand of drugs that’s all about science, not excess, and healing, not getting high.
With their products already in use in an increasing number of European countries, medical cannabis startups are further along this path than psychedelics startups, which are seeking to create a market from scratch — that is, once they’ve identified the best compounds for treatment and received regulatory approval. What ties the two together is the need for a methodical process to build trust in this new age of recreational drug turned therapeutic.
Early stage market map
Key stats
€13.8tn
projected costs of mental disorders by 2030 (including lost productivity)1
400m
number of Europeans who have legal access to medical cannabis2
€357m
projected sales of medical cannabis in Europe in 20223
Trends to watch
1. Virtual trip advisers
→ Psychedelic-assisted psychotherapy is a promising approach, but its growth is complicated by the need for therapists to stay with patients during their trips.
→ Startups are experimenting with digital guides and virtual therapists as well as shorter-acting psychedelics like 5-MeO-DMT to see if they can boost accessibility.
2. The perfect trip
→ Administering psychedelics is considerably more complex than regular antidepressants, with the colours and lighting of surroundings affecting the outcome, for example.
→ Running trials in connection with wearables could provide more data on responses, as would increasing the diversity of study participants.
3. Finding medical cannabis remains pot luck
→ The picture for medical cannabis remains messy across Europe, with countries offering different regulatory policies and insurance coverage, and prices for patients differing wildly as a result.
→ Beyond the issue of access, greater standardisation on quality will be needed to ensure the efficacy of treatment — and further increase adoption.
4. More potshots
→ The increased uptake of medical cannabis is creating opportunities for startups beyond cultivation and distribution. These could include optimising plant genetics or building consumption devices and patient data collecting apps.
→ Similarly, psychedelics startups could evolve beyond their risky biotech origins to running specialised clinics, manufacturing ingredients or developing support for digital therapy.
Startups tracked by Sifted
Investors by type
Sifted take
With laws becoming more lenient across Europe, the biggest barrier that medical cannabis startups still need to cross is the buy-in of doctors and physicians. In preparing for after their drug discovery efforts bear fruition, psychedelics startups would also do well to outline strategies to win over these key partners.
Rising stars
We identify companies as ‘rising stars’ using a number of criteria including founder backgrounds, investor track record, funding and valuation, and growth signals.
Has opened Europe's first commercial psychedelic research facility in London which provides the infrastructure drug development companies need to run clinical trials - for now focusing on psilocybin
Round
Seed
Date
2021
Size
€1.8m
Drug development company that uses yeast fermentation to produce psychedelics compounds which can otherwise be difficult to make in the quality required for clinical development.
Round
Seed
Valuation
Undisclosed
Date
2021
Size
€1.1m
Developing cannabinoid therapeutics for conditions that include autism, epilepsy and Alzheimer's. Founder Eduardo Sampaio previously cofounded Australia's fisrt marketplace fo hemp food products.
Round
Seed
Valuation
€40m
Date
2021
Size
€3m
Early stage startups to watch
Alphagreen Group
CBD
Consumer products
€4.1m
€2.8m
€14.6m
AVIDA Global
Cannabis
Cultivation
€3.2m
€1.3m
-
Becanex
CBD
Consumer products
€770k
€770k
-
Canax
Cannabis
Cultivation
€1.3m
€1.3m
-
Cannaable
CBD
Marketplace
€500k
€500k
-
Clerkenwell Health
Psychedelics
€2.2m
€1.8m
€11.2m
Daye
CBD
Consumer products
€5m
€5m
-
Grass & Co.
Consumer products
€2.5m
€1.2m
€7.5m
GreenLight Medicines Ltd
Cannabis
Therapeutics
€2.4m
€600k
€9.4m
Grow
Cannabis
Cultivation
-
€4.2m
-
Highline Wellness
CBD
Consumer products
-
€3.6m
-
Neurocentrx
Psychedelics
-
-
-
Octarine Bio
Psychedelics
€2.7m
€1.1m
-
ohne
CBD
Consumer products
€750k
€910k
-
Piauhy
Cannabis
Therapeutics
€4m
€3m
€40m
ProfesorCBD
Marketplace
€1.3m
€1m
€6.6m
Puresport
CBD
Consumer products
€250k
€250k
€320k
Rainbow
CBD
Consumer products
€3m
€2m
€12m
Signature Products GmbH
CBD
Consumer products
€1.3m
€800k
€5m
Tetra Pharm Technologiesc
Cannabis
Therapeutics
€2m
€2m
-
Thankyoujane / Cantura
CBD
Consumer products
-
€300k
-
The Beemine Lab
CBD
Consumer products
€1.2m
€900k
-
Voyager CBD
CBD
Consumer products
€1.2m
€1.2m
-
Wavepaths
Psychedelics
€4.1m
€4.1m
-
Yamnaya
CBD
Marketplace
€350k
€350k
-
Europe’s success stories
Who early stage startups are up against
(Pre-)Seed
Series A
Series B
Series C
Series D+
IPO/Exit
→ €1.9bn market cap
→ Has patented a synthetic version of psilocybin to treat depression
(Pre-)Seed
Series A
Series B
Series C
Series D+
IPO/Exit
→ €1.3bn market cap
→ Owns 10 companies each working on a different compound to treat mental health issues
(Pre-)Seed
Series A
Series B
Series C
Series D+
IPO/Exit
→ Vertically integrated cannabis company acquired for over €300m by Curaleaf
Sources
Research reports
The European Cannabis Investment Ecosystem | July 2021 | First Wednesdays
Succeeding in European Cannabis | December 2020 | Hanway Associates
3 The European Cannabis Report: 7th Edition | Prohibition Partners
News articles
Psychedelics startups are on a long journey to consumer markets, but these 5 VCs are taking the ride | May 2022 | TechCrunch
2 8 cannabis investors share their outlook on the European market in H1 2022 | April 2022 | TechCrunch
Psychedelics Stocks, Cannabis Stocks Shouldn't Trade the Same | November 2021 | Bloomberg
Startups are betting on a psychedelic gold rush | October 2021 | Vox
Psychedelic toad venom could soon be a clinical treatment for depression | August 2021 | Sifted
Investors are tripping on psychedelics startups despite a murky path to commercial success | August 2021 | Fierce Biotech
Psychedelics are getting closer to approval, but the market may not be ready | August 2021 | Fierce Biotech
Investors back a new era for mental health | June 2021 | Sifted
European companies set to dominate psychedelics market | March 2021 | Sifted
Psychedelics Replace Pot as the New Favorite Edgy Investment | December 2020 | Bloomberg
1 Psychedelic drugs may transform mental health care. And big business is ready to profit from the revolution. | February 2020 | Fortune
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