Cancer therapeutics
Startups summon strong medicine for tough fight
Last updated: 26 Jan 2023
Market 101
With cancer being one of the biggest killers worldwide, the impact of finding cures for it cannot be overstated. But as our knowledge of cancer has increased, so has the complexity of developing the right therapeutics for a disease that shows significant variability not just between types, but even for patients suffering from the same type.
Harnessing technologies from Crispr gene-editing to machine learning, startups are rising to the challenge of providing ever more personalised and precise treatments. But their focus isn’t just limited to therapeutics — companies are working on all sides of the equation, including detection and the delivery of care. Their improvements can’t materialise soon enough.
Early stage market map
Key facts
17
% of all deaths caused by cancer1
½
world population who will have cancer at some point in their lives2
10m
number of people who died from cancer in 20203
Trends to watch
Setting AI loose on cancer
With many cancers not untreatable as such, but simply discovered too late, one of the biggest ways to lower cancer deaths is early detection.
To support this work, startups are developing new technologies from liquid biopsies that use blood tests to detect cancer early to applying AI for better medical imaging.
Help for living with disease
For investors wary of deeptech, startups are developing apps that focus on how patients’ lives are affected by cancer treatment.
As a companion to treatment, these companies will likely generate revenue more quickly than their counterparts working on therapeutics.
Could CAR-T therapy prove revolutionary?
Cell therapies take a patient’s immune T-cells and engineer them to attack their tumour.
Since the first cell therapy was approved for blood cancer in 2018, companies have been working on expanding use cases and slashing costs by manufacturing off-the-shelf therapies rather than individually using each patient’s cells.
Cancer vaccines
Thanks to advances in genomic sequencing, scientists are able to design vaccines with much more specific targets. In the realm of cancer, most of these are meant to treat, rather than prevent the disease.
What sets this approach apart from other immunotherapies is the ability of a vaccine to teach cells to detect and destroy the cancer. So far, however, vaccines have mostly only been effective at eliminating small tumours.
Startups tracked by Sifted
Sifted take
New cancer treatments differ significantly both in their maturity and their areas of application. Startups need to make a case for how their approach is the most appropriately ambitious — both in terms of their chosen focus and the technologies they’re employing — to set them apart in a crowded field.
Rising stars
App that helps cancer patients report and monitor their symptoms, medications and activities. It was jointly cofounded by a doctor and former VP of data science who met through the Entrepreneur First accelerator.
Round
Seed
Valuation
Undisclosed
Date
2021
Size
€5,000,000
Is developing “artificial membrane-binding proteins” to support cell therapies. CEO Carolyn Porter previously oversaw the formation of 16 spinout companies at Oxford University.
Round
Seed
Valuation
Undisclosed
Date
2021
Size
€4,200,000
Provides a platform that enables personalised cancer therapeutics by replicating a patient’s genetic profile, screening drugs and recommending treatments. Founder Laura Towart previously founded an ovarian health company.
Round
Seed
Valuation
Undisclosed
Date
2021
Size
€1,200,000
Early stage startups to watch
AC Bioscience Ltd.
Novel therapeutics
Antibodies and immunotherapies
€6m
€2.5m
€33m
Blazar
Diagnostics
€350k
€135k
-
Careology
Treatment & care
App
€3m
€1m
-
Celeris Therapeutics
Novel therapeutics
€17.4m
€2.5m
€19.3m
Cureety
Treatment & care
App
€6.2m
€5m
-
CyGenica Limited
Novel therapeutics
€2.2m
€1.3m
-
Cytoseek
Novel therapeutics
Cell therapies
€5.5m
€4.2m
-
FrontWave Imaging SL
Novel therapeutics
Antibodies and immunotherapies
€834k
€814k
-
Libera Bio
Novel therapeutics
Antibodies and immunotherapies
€3.8m
€1.3m
-
Medical Templates AG
Treatment & care
Radiation
€4.5m
€3m
-
My Personal Therapeutics/ Vivan Therapeutics
Novel therapeutics
€6.1m
€1.2m
-
NU-RISE
Treatment & care
Radiation
€500k
€1.5m
€9m
QV Bioelectronics
Treatment & care
Medical device
€3.2m
€835k
-
Spirea
Novel therapeutics
Antibodies and immunotherapies
€3.3m
€2.3m
-
Vinehealth Digital
Treatment & care
App
€7.7m
€5m
-
Sources
News articles
See the pitch deck that cancer detection startup OXcan used to raise $3.7m | January 2023 | Sifted
Four New Technologies That Will Change Cancer Treatment | October 2019 | Labiotech.eu
How new technologies are transforming cancer treatment | July 2021 | Fortune
6 experts reveal the technologies set to revolutionize cancer care | February 2022 | Weforum
Resilience is an ambitious bet to improve cancer treatment | March 2021 | TechCrunch
These startups aim to help cancer patients beyond the oncology ward | February 2022 | Fast Company
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